About this item

• Healthy Methylation: Methyl-Guard Plus supports methylation and promotes a healthy level of homocysteine
• Active Forms: Formulated with active folate (5-MTHF) and the active, tissue-ready forms of vitamins B2, B6, and B12 to optimize absorption
• Free From: Doesn't contain gluten, eggs, tree nuts, peanuts, dairy, soy, fish, or shellfish
• Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners
• Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners

Product Description

Support optimal health with Thorne Methyl‑Guard Plus—a premium, 90‑capsule formula delivering bioactive B vitamins and methyl donors to promote efficient methylation, balanced homocysteine, and enhanced energy, mood, and cognitive function.

🔹 Key Ingredients & Benefits:

• 5‑MTHF (L‑5‑methyltetrahydrofolate) – active folate that bypasses genetic conversion issues (such as MTHFR), supporting DNA synthesis & cardiovascular health

• Methylcobalamin (B12) – bioavailable form key for nervous system function and red blood cell formation

• Riboflavin 5′‑phosphate (B2) & P‑5‑P (B6) – essential cofactors in methylation, neurotransmitter production, energy metabolism, and homocysteine regulation 

• Betaine (Trimethylglycine) – potent methyl donor supporting liver detoxification, fat metabolism, and lean body composition 

⭐ Benefits at a Glance:

• Supports methylation, essential for DNA repair, detox, mood, and cognition 

• Helps maintain healthy homocysteine, supporting heart, brain, and bone health 

• Boosts cellular energy, reduces fatigue, and supports metabolic balance

• Enhances neurotransmitter synthesis, improving focus and mood 

• Supports liver detoxification, fat metabolism, and lean body composition 

✅ Features:

• 90 capsules; recommended 1–3 capsules daily (typically 2 daily with meals)

• Gluten-, dairy-, soy-free; GMP‑certified & formulated for individuals with MTHFR variations 

• Made in the USA in a cGMP facility.

Methyl‑Guard Plus by Thorne is a high-potency supplement featuring methylated B‑vitamins and betaine, crafted to support the body's methylation cycle—a vital process for cardiovascular health, energy production, brain function, detoxification, and mood regulation. This product is excellent for individuals with MTHFR gene variants or those seeking advanced metabolic support 

What Makes It Special?

5‑MTHF – The Active Folate

By delivering the bioactive form of folate, 5‑MTHF, methyl-Guard Plus ensures absorption even in those with MTHFR mutations—supporting DNA creation, healthy homocysteine, and heart health

Methylcobalamin (B12)

This methylated form supports neurological health and effective energy metabolism, ideal for those with absorption challenges

B2 & B6 – Methylation Cofactors

Riboflavin 5′-phosphate and P‑5‑P support enzyme reactions in methylation, neurotransmitter production, and detox pathways

Betaine (TMG)

A powerhouse methyl donor supporting liver detox, lean muscle metabolism, and balanced homocysteine 

Advantages You Can Expect

Usage & Safety

• Recommended dose: 1–3 capsules daily with meals; common dose is 2 capsules

• Adjust dosing: Sensitive individuals may start with 1 capsule, monitor reactions 

• Warnings: Possible mild insomnia, jitteriness, or digestive changes in sensitive users—reduce dose as needed 

• Quality: No gluten, dairy, soy; manufactured in a cGMP facility; 30-serving container 

Real‑World Feedback

• A Walmart reviewer noted:

  “Great supplement for those with MTHFR genetic mutations and who cannot methylate folate,” recommended by a physician

• However, some Reddit users report excessive B dosage causing insomnia or irritability—suggest trialing lower doses

Who It’s Best For

• Individuals with MTHFR or methylation gene variants

• Anyone needing homocysteine support for heart and bone health

• People seeking organic energy/mood support without stimulants

• Those focused on detox, lean muscle metabolism, and healthy aging

Conclusion

Thorne Methyl‑Guard Plus is a top-tier methylation supplement combining active folate, B12, B2, B6, and betaine—designed to support cardiovascular health, energy levels, mood balance, and detoxification. With a clinically-informed formula and quality assurance, it’s a smart choice for those looking to enhance foundational metabolic processes. Start with 1–2 capsules and adjust based on tolerance for optimal results.

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